Waters Laboratory Application Articles and Scientific Posters

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Analysis of Tricyclic Antidepressants in Human Urine Using UltraPerformance Convergence Chromatography (UPC²)
24 May 2013

Tricyclic antidepressants (TCAs) are an older class of drug traditionally analyzed using GC, UV, or LC/MS. This application note describes the successful implementation of UltraPerformance Convergence Chromatography™ for the analysis of and quantification of four TCAs in human urine. Results demonstrate the utility and benefits of this novel separation technology in the important application area of bioanalysis.

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Streamlining and Non-Compliant Intact Mass Analysis of Biotherapeutic mAbs with the Biopharmaceutical Platform Solution	monoclonal antibodies, therapeutic antibodies	23 May 2013	Read
Investigating the Applicability of Direct Analysis and Ion Motility TOF MS for Environmental Analysis	pesticides, environmental contamination, ion separation	22 May 2013	Read
Novel Data-Independent MALDI Imaging Ion Mobility Acquisition for the Visualization and Identification of Proteins Directly from a Single Tissue Section	tissue processing, colon cancer, imaging	20 May 2013	Read
Advantages of Online 2D Chromatography for MRM Quantification of Therapeutic Monoclonal Antibodies in Serum	monoclonal antibodies, MRM, therapeutic antibodies	14 May 2013	Read
Determination of Melamine Residue in Water Samples by UPlC/MS/MS	drinking water analysis, melamine, water analysis	14 May 2013	Read
Investigation into the Mechanisms of Prostate Cancer Androgen Independence Using Label-Free Data-Independent Quantitative LC-HDMSE and Pathway Analysis	Label-Free Analysis, prostate cancer	10 May 2013	Read
UPLC Analysis of Benzalkonium Chloride (BAC) in Consumer Products using ACQUITY UPLC CSH C18	wastewater, environmental contamination, USP method	8 May 2013	Read
Characterization of Antibodies and Antibody Drug Conjugates by a Novel High Resolution Quadrupole Time-of-Flight Mass Spectrometer	monoclonal antibodies, conjugation, antibody drug conjugates	8 May 2013	Read
Targeted Metabolomics Using the UPLC/MS-based Absolute IDQ p180 Kit	metabolites, metabolomics, biomarker discovery	7 May 2013	Read
Metabolic Characterization of Tumor-Tumor Microenvironment Interactions in Human Colorectal Cancer using MALDI Mass Spectrometry Imaging	colorectal cancer, tumor, metabolomics	3 May 2013	Read