Drug-to-Antibody Ratio (DAR) Calculation of Antibody-Drug Conjugates (ADCs) Using Automated Sample Preparation and Novel DAR Calculator Software
23 September 2016

Antibody-drug conjugates (ADCs) are a new class of biotherapeutics that represent a rapidly growing portion of the drug discovery pipeline in pharmaceutical companies. This application note explains why LC/MS is a popular analytical method for measuring the DAR and the drug load distribution of ADCs; and show that the Agilent AssayMAP Bravo is an easy-to-use automated sample preparation system that gives great reproducibility.