Analysis of Extractable and Leachable Compounds from Transdermal Patches Using GC/MSD Systems
22 April 2015

In this application note, a lidocaine adhesive patch and film release liner were used to investigate extractable and leachable compounds in transdermal drug delivery systems using two Agilent 5977A Series GC/MSD Systems. Plastic and adhesive additives were identified in acetone, dichloromethane, and hexane extracts using the large volume liquid injection technique. Pharmaceutical ingredients were also identified using high temperature headspace and liquid sampling techniques.