Phenotypic Screening of a Full Compound Library: A Reality or A Pipe(Line) Dream?
3 May 2016
The search for new drugs is getting increasingly more difficult. This is due to a variety of factors, but the main ones are: the ‘low hanging fruit’ has already been identified and the regulatory hurdles to overcome are becoming ever more numerous and becoming increasingly more difficult to pass. This has resulted in a high rate of attrition, with many candidates failing very late in clinical trials due to safety/toxicity concerns as opposed to lack of efficacy, incurring enormous financial losses. This white paper explores the options available for the screening of entire compound libraries in a phenotypic manner.