SB431542 is a selective and potent inhibitor of the TGF-β/Activin/NODAL pathway that inhibits ALK5 (IC₅₀ = 94 nM), ALK4 (IC₅₀ = 140 nM), and ALK7, but does not inhibit the BMP type I receptors ALK2, ALK3, and ALK6. (Inman et al., Laping et al.)
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