iCell® GABANeurons Kit, 01279 by STEMCELL Technologies Inc.

Traditional neuroscience research tools consist largely of rodent primary cell cultures and animal models, which are labor-intensive, costly, and poorly reflective of native human biology. iCell® GABANeurons represent a relevant human in vitro system for modeling and interrogating complex neurological processes and diseases.

iCell® GABANeurons are induced pluripotent stem (iPS) cell-derived mixed populations of human cerebral cortical neurons that exhibit native electrical and biochemical activity. They overcome limitations of existing models by providing the following:

• > 95% pure population of primarily GABAergic (inhibitory) neurons
• Rapid formation of neural networks and functional synapses
• Expression of relevant neurological therapeutic targets and pathways
• Long-term viability and demonstrated reproducibility
• Reliable supply in cryopreserved format

There is a broad range of peer-reviewed publications and CDI application protocols and applications notes to support your research goals, including:

• Alzheimer’s disease research and drug discovery: Functional tau and β-amyloid toxicity pathways, long-term viability, and flexible product format enable high-throughput screening for novel drug candidates
• Autism disease research: Demonstrated prefrontal cortex ionotropic glutamate receptors, GABAA receptor, and synaptic functionality drive interrogation of neurological diseases, such as autism
• Infectious disease studies: Susceptibility to varicella zoster virus infection and ability to maintain viral latency and reactivation
• Therapeutic potency testing: High sensitivity, dose-response, and biological responses to Clostridium botulinum neurotoxin (BoNT) aid replacement of the gold-standard mouse bioassay for BoNT potency testing
• Neurotoxicity assessment: Compatibility with a wide range of high-content, high-throughput platforms enables assessment of pharmaceutical and environmental neurotoxicity