CYP2J2 is expressed at high levels in cardiac tissue. It is expressed at lower levels in the intestine, liver, kidney, and lung. CYP2J2 is active for the oxidation of arachidonic acid to epoxyeicosatrienoic acids (EETs), which are important for heart and kidney function. CYP2J2 has also been shown to metabolize xenobiotics such as diclofenac and bufuralol. CYP2J2 is the predominant P450 for the hydroxylation of ebastine and astemizole (non-sedating anti-histamines) in human intestinal microtomes. More recent studies have shown that CYP2J2 is a high affinity enzyme for the hydroxylation of terfenadine.
Manufacturer Corning Life Sciences | Available in North America, Western Europe, Asia, Eastern Europe, Middle East, Africa
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