Corning® Supersomes™ Human CYP2E1 + Oxidoreductase + b5, 1 nmol by Corning Life Sciences

CYP2E1 is constitutively expressed in the human liver and subject to induction by a variety of mechanisms including protein stabilization by substrate. Isoniazid is a known CYP2E1 inducer as well as many small organic compounds such as acetone and ethanol. Physiological conditions such as fasting, diabetes, and obesity can induce CYP2E1.

CYP2E1 is capable of activating the procarcinogens N-nitrosodimethylamine and N-nitrosodiethylamine (a high affinity form) and also metabolizes the procarcinogens: benzene, styrene, carbon tetrachloride, methylene chloride, methyl chloride, chloroform, 1,2-dichloropropane, 1,2-dichloroethane, 1,2-dibromoethane, vinylchloride, vinlybromide, arylonitrile, vinylcarbamate, ethylcarbamate, trichloroethylene, chlorinated benzenes, lauric acid, and butadiene. The skeletal muscle relaxant, chlorzoxazone, is a selective substrate for CYP2E1. CYP2E1 is responsible in part for the metabolism of acetaminophen to a reactive intermediate which can cause severe liver damage. However, CYP2E1 has not been found to play a significant role in the metabolism of many other drugs.