From KNAUER, Simulated Moving Bed - The Next Step in Chromatography!
Preparative chromatography (Simulated Moving Bed) is increasingly applied as a separation technique in the pharmaceutical industry, production of fine chemicals, and in the field of bioengineering.
Why Simulated Moving Bed?
Simulated Moving Bed is a method in process chromatography that enables substance mixtures to be continuously separated and extracted in two fractions. By repeated use of the SMB process each partial fraction can be separated into a further fraction - up to binary substance mixtures. Typically, the SMB process is set up in advance for a two component mixture. Following this, both substances can be immediately extracted in pure form - up to 1,000 kg per year.
Where can a SMB separation be used?
The SMB principle for continuous extraction of pure substances on a preparative scale is successfully used in several areas of chemistry and biochemistry. The yearly production of the offered systems is between 100 and 1,000 kg per year.
- continuous liquid chromatography technique for highest efficiency
- product purification at the kg scale
- maximum overloading of stationary phase
- up to 90% less solvent consumption