Avanti® Polar Lipids 08:0 PI(4,5)P2 by Merck KGaA, Darmstadt, Germany

Manufacturer Merck KGaA, Darmstadt, Germany | Model: 850185P | Available in Western Europe, Asia, Eastern Europe, South Central America, Caribbean, Australia Oceania, Middle East, Africa, Other

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1,2-dioctanoyl-sn-glycero-3-phospho-(1'-myo-inositol-4',5'-bisphosphate) (ammonium salt), powder

Avanti® Polar Lipids 08:0 PI(4,5)P2

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Although PI(4,5)P2 is a minor component of cell membranes, it plays a critical role as a substrate for a number of important signaling proteins. PI(4,5)P2 is an intermediate in the IP3/DAG pathway where it is hydrolyzed by phospholipase C to liberate the second messengers, inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). PI(4,5)P2 is also a substrate for PI 3-kinase where it is phosphorylated to PI(3,4,5)P3, an activator of downstream signaling components such as the protein kinase AKT. The dioctanoyl derivative of PI(4,5)P2 is more water soluble than its long chain counterparts.

Packaging

2 mL Amber Serum Vial with Stopper and Crimp Cap (850185P-100ug)
2 mL Amber Serum Vial with Stopper and Crimp Cap (850185P-500ug)

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