ApoE Knockout Rabbit by SAGE Labs

Manufacturer SAGE Labs
Rabbits are a preferred model in hypertension and atherosclerosis studies due to their convenience of various physiological and surgical manipulations. ApoE Knockout rabbits have drastically elevated cholesterol and triglycerides, making it an excellent model of human heart disease. ApoE Knockout Rabbit Characteristics: 8 bp deletion within Exon 3 Homozygous knockouts exhibit complete loss of ApoE protein via Western blot At four months of age, ApoE knockout rabbits demonstrate serum ch... Read more


ApoE Knockout Rabbit by SAGE Labs product image
ApoE Knockout Rabbit

The supplier does not provide quotations for this particular product through SelectScience. You can search for similar products in our product directory.



0 Scientists have reviewed this product


Write the First Review

No Reviews

Rabbits are a preferred model in hypertension and atherosclerosis studies due to their convenience of various physiological and surgical manipulations. ApoE Knockout rabbits have drastically elevated cholesterol and triglycerides, making it an excellent model of human heart disease.


ApoE Knockout Rabbit Characteristics:

  • 8 bp deletion within Exon 3
  • Homozygous knockouts exhibit complete loss of ApoE protein via Western blot
  • At four months of age, ApoE knockout rabbits demonstrate serum cholesterol levels 2-5x greater than wildtype
  • At four and five months of age, ApoE knockout rabbits demonstrate triglyceride levels up to 2x greater than wildtype
  • Background Strain: New Zealand White

Research Applications:

  • Atherogenesis
  • Atherosclerosis
  • Hypertension
  • Insulin resistance
  • Lipoprotein/Cholesterol transportation
  • Metabolism (Triglyceride/Cholesterol)
  • Obesity
  • Type II diabetes