ACQUITY UPLC H-Class PLUS System by Waters

"When it comes to accuracy, precision and sensitivity in the detection and quantification of metabolites, the first name that comes to mind is Waters UPLC. What more to say? Use once and you will never look back."

"This HPLC features a wide range of modules and components, including data systems, with an outstanding lifetime, high precision, and practically maintenance-free operation. Waters has the resources to meet user requirements in nearly every market and application."

"Great, robust UPLC that comes with great service and the most intuitive LC software to date. "

"We really like Waters technology. It offers reliable solutions and full-time follow-up. Their instruments are easy to access and are easy to use. For me Waters is better than other manufacturers. With Waters, my analyses have become faster."

"The instrument is absolutely wonderful. Coming from grad school to the professional world, getting to use the H-class was lightyears ahead of what I had access to before. It makes method development a breeze."

"Reliable, stable, easy to use and a must-have instrument in any QC lab. It's perfect to upgrade from HPLC to UPLC, and to meet pharmacopoeial requirements, so it enables the laboratory to have more flexibility in testing."

"Water Acquity H-Class UPLC is a very robust technology in terms of efficiency and reliability of results. It's a very user friendly analytical instrument with good accuracy of results. Ease of use and after sale service are phenomenal."

"Very nice equipment, reliable and worth the money."

"The time to analyse a sample is shorter with the minimum sample size compared to a normal HPLC, and it can analyse multiple samples per run.The technical team is useful and always give consultation when I encounter a problem."

"The Waters H-Class ACQUITY allows accurate samples to be analyzed within a very short period of time. Excellent instrument."

"The second generation of a workhorse product that is just as good as the orginal."

"Product got good values but product breaks down often. Used it for marijuana research to compare with a different LC and got better numbers."

"The instrument works very well. Fast runs and easy to control."

"Water's H-Class UPLCs are robust and very efficient for separation/detection when used in conjunction with UPLC columns. Their ability to withstand very high backpressures enables users to operate at faster rates, higher throughputs and much higher accuracy level. They are an excellent tool for any pharmaceutical development lab (predominantly CDMO) as you can screen, develop, optimize and validate your methods in a short period of time compared to traditional HPLCs."

"This is a great UPLC system which can also be used for HPLC purposes. Reproducibility is very good. The consumables are easy to self replace. Also their after purchase service is great. I use this instrument to do method development and validations, and it has worked amazingly for me."

"Excellent UPLC capabilities and great customer support."

"Excellent support, excellent UPLC. Reliable instrumentation. "

"Flexibility and robustness to run all the chromatographic modes. Improve characterization of your complex samples. Streamline your method development workflow. Support of your existing HPLC, UHPLC, and UPLC methods."

"Very effective uplc/uhplc system. In combination with empower software is very user friendly."

"The instrument delivers high quality results. The customer service is wonderful. The Empower software is not very easy to master, so I would give that element 3 stars."

"A great product for method development. The quaternary pump allows for highly complex LC methods, and the multi column housing allows for easy changes between columns during method development."

"Using the Empower Software is very difficult at first but once you get used to it, you will realize that it is a very good software. Why? Because it keeps the integrity of your data. No matter how many times you re-process your chromatogram, it will keep the integrity of your original data by creating a new version every time a change is made on your chromatogram. Data integrity is an integral aspect in every laboratory. Also, Empower software is fully compliant with the requirements stated in 21 CFR Part 11 which is specific on electronic records and electronic signatures. "

"Very versatile model with a very user-friendly Empower software system."

"I love our H class UPLC system from Waters. We use it extensively for method developments and then for routine analysis after method validation. System is robust and reliable. Does not require a lot of service (so far, our system is relatively new). I think that system already pays off itself. "

"High quality results, complex to use. Recommend to others"

"This product was effective in shortening the run times of HPLC methods. It was easy to use with high quality results. I can recommend if someone asks. After sales care was good with service and application support. Would be happy if can be bargained for less :-)"

"This instrument is high quality and ease-to-use. The technical service after sale is good and it offers value for the money although it is more expensive than HPLC."

"A very reliable an versatile UHPLC system. The reduced dead volume is really adapted to the new sub nano particles UPLC columns."

"Acquity UPLC H-Class System is very easy to use and if you have problems, you do not need to call for service at once as you can do most of the things by yourself. The parts, if they need to be changed, are not too expensive. A little problem is that nobody has educated us how to use such instrument, we had to do it by ourselves through practice."

"The software is easy to use. I can organize my runs by injection or by project. The only downfall is that HPLC protocols do not translate to UPLC...you may need to do some method development. I would recommend to a colleague since Waters is the world's leader in UPLC systems."

"The H-Class system is a valuable instrument for screening various buffers in ion-exchange methods with the quaternary pump and the Empower software developed to optimize pH and  salt gradients. The flowthrough needle allows for much less worry of carryover over the traditional Acquity instruments."

"Very easy to use. It gives the user the option to use as HPLC as well as UHPLC. Very convenient for method development as the pump can be used individually."

"This instrument is very straight forward and is easy to use; once the sample is put into the sample chamber, and the conditions are set up, a sample set can be run overnight, with the option of automatic shut off after the last batch.  I would eagerly recommend this to a colleague.  Although I learned how to use the system with little trouble, my trainer had to learn how to use it by trial and, so I suppose a training session by a professional would be beneficial."

"Practical application, good performance in Method Transfer from HPLC to UPLC."