The Port-a-Patch is a very compact single-channel bench-top workstation. Chip mounting station and amplifier head-stage are integrated in the shielded device, while an additional small suction control unit, a patch-clamp amplifier and a computer complete the system. However, it was further miniaturized by integrating the amplifier into the system in case of Port-a-Patch mini. Using this semi-automated patch clamp system is very easy. The user just pipettes solutions and cells onto the disposable recording chip, where a cell is automatically captured and sealed using the suction control unit. Visual control of this process by microscope and micro-manipulator are not required. Many add-ons, such as temperature controlled external perfusion system or the unique internal perfusion system expand the range of possible experiments can be performed by this device. Very impressive technology and system for quick test of cells and ion channels. However, for higher throughput, I recommend the Patchliner or SyncroPatch from Nanion, where 8 or 384 wells are recorded in parallel, respectively. In addition to state-of-the-art and reliable instruments, the experienced team at Nanion provide exceptional support and technical background to develop the experimental methods and achieve the best quality records.