Scientists in academic, government and biopharmaceutical laboratories who are faced with increasingly complex research challenges now have access to a digitally advanced Thermo Scientific Orbitrap Tribrid mass spectrometry (MS) platform that includes a new high-performance MS with inherent flexibility and built-in intelligence to enable critical insights and breakthroughs.
The new Thermo Scientific Orbitrap Eclipse Tribrid mass spectrometer features important advancements that improve system sensitivity over previous generations and expand its ability to characterize and quantify complex biomolecules and biological systems. These enhancements are ideal not only for native omics and translational research, but also for the structural and biopharmaceutical analysis of intact proteins and their complexes.
The real-time capabilities of the Orbitrap Eclipse Tribrid mass spectrometer use the latest, built-in intelligence-driven data acquisition strategies to enhance experimental efficiency and ultimately accelerate tandem mass tagging (TMT) for multiplexed quantitative analysis of proteomes. Peptide spectra are searched in real-time against a study-specific database. Those that match then proceed for further analysis, significantly increasing the speed of analysis and accuracy of results. In addition, the new system extends structural analysis up to m/z 8,000, which enables the isolation and selective dissociation of protein complexes into their individual components, as well as revealing further insights about their exact structure.
Thermo Fisher Scientific is showcasing its new Orbitrap Eclipse Tribrid instrument during the 67th American Society for Mass Spectrometry (ASMS) Conference on Mass Spectrometry and Allied Topics, being held June 2–6, in the International Ballroom ABCD at the Omni CNN Center Hotel, Atlanta, Georgia.
Steven Gygi, PhD, professor of cell biology at Harvard Medical School, said, "My research group is investigating subtle proteome-wide responses to environmental, pharmacological, pathological or genetic changes, which can often be challenging and time-consuming to detect and quantify. With the real-time searching capabilities, the Orbitrap Eclipse Tribrid mass spectrometer helps us to quickly decide the mass spectra we need to acquire during our experiments, which drastically reduces the number of scans we need to perform and the time it takes to obtain the results that matter most to us."
"With protein-based discoveries advancing at a remarkable pace, leading researchers understandably demand that analytical technologies keep up with their progress and advances in experimental design," said Iain Mylchreest, vice president, R&D, for Thermo Fisher’s analytical instruments business. "The new Orbitrap Eclipse instrument fundamentally improves the sensitivity, speed and accuracy of quantitative proteome analysis, enabling scientists to comprehensively define proteoforms and protein complexes at an unprecedented level of detail."
Users of the Orbitrap Eclipse Tribrid mass spectrometer can benefit from:
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