Product News: Extensive CAR-T Cell Range for Research & Immunotherapy

The new range adds to AMSBIO’s growing product offering which includes engineered cell lines that aim to support custom development in applications including animal studies

11 Jul 2019


AMSBIO has announced new CAR-T cells, engineered CAR-T target cells, PBMC, cell media and activation beads in response to the rapid growth in research on the therapeutic uses of CAR-T cells.

All CAR-T cell products from AMSBIO are T cells produced from either a group of donors or from individual donor transduced with CAR (Chimeric antigen receptor) - lentivirus.

These CAR-T cells can target different tumor antigens such CD19, CD133, Her-2, EGFR, VEGFR-2 or mesothelin that are highly over-expressed in tumors. These CAR-T cells can express inducible caspase-9 or other suicide gene to induce CAR-T cell killing for increased safety in case this construct in future will be proposed to use in clinical trials. All CAR-T cell products from AMSBIO can be validated for transduction efficiency, cell killing activity and Real time cytotoxicity activity. All CAR-T cells from AMSBIO have negative mock controls: lentivirus-transduced CAR-T cells, no ScFv-transduced CAR-T cells and non-transduced T cells.

In addition to these off-the-shelf CAR-T cell products, AMSBIO offers a growing list of engineered cell lines including CAR-T/NK cells and target cells (GFP-Raji cells) to support custom development in applications including animal studies.

PBMC (Peripheral Blood Mononuclear Cells) from AMSBIO are isolated from blood samples using standard Ficoll-Paque and density gradient centrifugation. These PMBC cells can be used for isolation of T cells (used to generate CAR-T cells) and other cell types.

AMSBIO's new CAR T-cell Expansion Medium is specifically optimized for expansion of CAR T-cells, providing 100-fold greater expansion than normal media. CD28 / CD3 cell activation / expansion beads have been introduced to enable researchers to activate and expand human T cells: CD4+, CD8+ T cells, antigen specific T cells or polyclonal T cells.

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