Expert Insight: High-throughput antibody discovery targeting cell surface receptors for signaling blocking in cancer

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Tracey Mullen, Chief Operating Officer, Abveris and AbX Biologics

The use of monoclonal antibody-based therapeutics to target and treat cancer is considered to be one of the most successful therapeutic strategies within the oncology field to date. Both unconjugated and conjugated antibodies are currently approved by the FDA for cancer therapy, capitalizing on methods of action spanning from direct inhibition of cell survival pathways to the delivery of cytotoxic drugs. Specific cell surface antigen recognition is paramount to the success of these drugs, necessitating high-resolution, early-stage characterization of lead antibody drug candidates prior to preclinical development.

Major advancements in high-throughput flow cytometry have enabled more thorough analysis of on-cell antigen specificity and function earlier in the drug discovery process, allowing for more exquisite antibody discovery within the oncology field. In this webinar, Tracey Mullen, COO of Abveris, will review an antibody discovery campaign targeting a cell surface receptor implicated in cancer. Methods for immunization, antibody discovery, and subsequent functional characterization will be detailed.

In this webinar, you will cover:

• A detailed overview of high throughput antibody characterization in antibody discovery workflows
• The importance of leveraging high-content screening as early in the discovery process as possible to improve likelihood of campaign success

Who should attend?

• Antibody discovery scientists and researchers engaged in therapeutic drug discovery in oncology indications
• Anyone interested in learning more about incorporating high-throughput flow cytometry analysis into early-stage research and development

The live webinar and Q&A session will take place on Tuesday, April 28, at:

• 16:00 BST
• 11:00 EDT
• 08:00 PDT
• 17:00 CEST

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