Application Note: LC-MS/MS Screening of 64 New Psychoactive Substances Using Dried Blood Spots
5 September 2014

This application note describes a robust, fast, sensitive and specific LC-MS/MS screening method for the determination of 64 new psychoactive substances (NPS) in dried blood spots (DBS) using an AB SCIEX QTRAP® 5500 LC/MS/MS System. DBS provide fast and efficient sample preparation and are easy to handle in terms of further preparation steps and shipping. Only low sample volumes of capillary blood are required which can be obtained through minimally invasive techniques compared to blood sampling via venipuncture.