Application Note: FRET-Based Screening for Potential Modulators of G Protein/GoLoco Interaction
17 November 2009

A CFP-YFP FRET based assay was utilized to screen for potential inhibitors of the G protein/GoLoco interaction. Inhibitors of that interaction are putative pharmacological tools. The POLARstar Omega proved to be a reliable and robust instrument to perform these FRET based measurements. With the MARS Data Analysis Software, the FRET ratio and Z’ value are automatically calculated providing fast and efficient evaluation.