Application Note: Determination of Acrylamide in Fried Potato Chips by Discovery DSC-MCAX (Mixed Cation) and DSC-18 (C18) SPE, and Discovery HS F5 (Pentafluoropropylphenyl) LC-MS
5 June 2009

This application note descibes a simple sample prep method using mixed-cation SPE phase connected in tandem with a C18 SPE phase. This method eliminates the need for extensive derivatization to produce sufficient retention and detections. The unique selectivity of Discovery HS F5 HPLC offered good retention of acrylamide while maintaining good peak shape with a totally aqueos system.