Application Note: Cell-based screening for drug‑induced mitochondrial toxicity
20 January 2020
The importance of the mitochondrial network as a site for off-target drug effects highlights the need for in vitro assays capable of detecting drug-induced mitochondrial liabilities. However, conventional cytotoxicity assays are particularly unsuited to this task due to the ability of relevant cell lines to circumvent the down-stream implications of perturbed mitochondrial function. This application note describes how the Agilent MitoXpress Xtra oxygen consumption assay is designed to be used to address this deficit.