Application Note: Cancer Immunotherapy Applications of xCELLigence® Real-Time Cell Analysis (RTCA) Systems
29 April 2016

Cancer immunotherapy consists of multiple approaches that focus on harnessing and enhancing the innate powers of the immune system to fight cancer. While traditional small molecule chemotherapy continues to play a critical role in cancer treatment, immunotherapy is rapidly gaining traction. Many in vitro assays have been developed to screen and evaluate the efficacy of immune cell-mediated killing, but while they still serve as important tools, there is a critical need for more efficient, homogeneous, automated assays that aren’t hampered by the artifacts and hassle of using labels and that can provide quantitative results. This application notebook explains how xCELLigence RTCA systems can be used to monitor immune cell-mediated killing, using examples such as NK cell-mediated cytolysis, T cell-mediated cytolysis and Antibody-Dependent Cell-Mediated Cytolysis (ADCC).