Application Note: Analysis of RNA Polymerase II Mutants Using the xCELLigence System
1 May 2018
Recent studies on RNA polymerase II suggest that it serves as an integrator of signaling events for regulating gene expression at multiple levels. During the transcription cycle, differential phosphorylation of the C-terminal domain (CTD) of RNA polymerase II may occur, leading to specific functionality and control. In this application note, researchers utilize the xCELLigence system to explore the functions of the C-terminal domain of RNA polymerase II and the effect of its modifications.