Application Note: A Rapid Assay for p450 Inhibition/Induction Utilizing UPLC and Tandem Quadrupole MS
9 May 2008

A significant number of candidate medicines fall out of the development process due to toxicity. The later this occurs in the discovery/development process, the more costly it becomes. This application note from Waters investigates the use of the increased chromatographic efficiency of UltraPerformance LC® (UPLC®) and its sub-2 µm particles to deliver improved performance and faster analysis for toxicity studies.