Monoclonal Anti-Vinculin antibody produced in mouse

4.0
/
5.0
  |  1 reviews


Product Details

Manufacturer
Cat. No.
V9131-.2ML
Type
Primary Antibody
Clonality
Monoclonal
Host
Mouse

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Description

Vinculin is a cytoskeletal protein associated with the cytoplasmic faces of both cell-cell and cell-extracellular matrix adherens-type junctions that functions as one of several interacting proteins involved in anchoring F-actin to the membrane. The sequences of chicken, nematode and human vinculin have been determined.A sequence of molecular interactions might be involved in the transmembrane assembly of adhesion plaques. In the assembly of adhesion plaques, the ß-subunit of integrin binds to talin. Talin binds to vinculin that interacts with a-actinin and possibly with itself. Since a-actinin binds to and cross-links actin filaments, vinculin represents a key element in the transmembrane linkage of the extracellular matrix to the cytoplasmic microfilament system. In muscle, vinculin is localized in the fascia adherens of the intercalated disk (cardiac muscle), myotendinous junctions (skeletal muscle), neuromuscular junctions and the membrane-associated dense bodies of smooth muscle. In many cell types undergoing viral transformation, vinculin becomes redistributed to rosettes or podosomes.

Alternative Names

Anti Vinculin, Vinculin Antibody - Monoclonal Anti-Vinculin antibody produced in mouse, Vinculin Antibody

Biological Information

Clonality Monoclonal
Host Mouse
Reactivity Bovine, Chicken, Dog (Canine), Frog, Human, Mouse, Rat, Turkey
Isotype IgG1

Handling

Storage -20°C

Applications

Immunofluorescence (IF), Immunohistochemistry (Paraffin-Embedded Sections) (IHC (P)), Western Blotting (WB)

Average Rating: 4.0
1 Scientist has reviewed this product

4 out of 5
Specificity
4 out of 5
Sensitivity
4 out of 5
Quality

Performs well.
Rating: 4.0

  • Application Area: Immunohistochemistry

  • Sample/Target/Tissue: Schwann cell surface interaction
"The product is quite specific, but even with all the appropriate blocking, we see some unspecific binding."

Review date: 04 Dec 2018 | Monoclonal Anti-Vinculin antibody produced in mouse

Antibody Overview

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Monoclonal Anti-Vinculin antibody produced in mouse

4.0 / 5.0 | 1 reviews

Manufacturer:
Catalogue Number:
V9131-.2ML
Antibody Type
Primary Antibody