ASC Antibody (B-3)

4.0
/
5.0
  |  1 reviews


Product Details

Manufacturer
Cat. No.
sc-514414
Type
Primary Antibody
Clonality
Monoclonal
Host
Mouse

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Santa Cruz Biotechnology Inc.

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Description

Caspase-associated recruitment domains (CARDs) mediate the interaction between adaptor proteins such as Apaf-1 and the proform of caspases (e.g., CASP9) participating in apoptosis. ASC (apoptosis-associated speck-like protein containing a CARD, also known as TMS1or PYCARD) is a member of the CARD-containing adaptor protein family. ASC is a 195 amino acid protein, containing a N-terminal Pyrin-like domain (PYD) and an 87 residue C-terminal CARD. This motif is characteristic of numerous proteins involved in apoptotic signaling. Fluorescence microscopy demonstrates a ring-like expression in some transfected cells. Immunofluorescence microscopy demonstrates that induction of apoptosis causes a CARD-dependent shift from diffuse cytoplasmic expression to punctate or spherical perinuclear aggregates. Western blot analysis shows expression of ASC in leukemia and melanoma cell lines. ASC exhibits intriguing behavior by forming an aggregate and appearing as a speck during apoptosis induced by retinoic acid and other anti-tumor drugs. The ASC gene maps to human chromosome 16p11.2.

Biological Information

Clonality Monoclonal
Host Mouse
Reactivity Human, Mouse, Rat

Applications

ELISA (ELISA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-Embedded Sections) (IHC (P)), Immunoprecipitation (IP), Western Blotting (WB)

Average Rating: 4.0
1 Scientist has reviewed this product

4 out of 5
Specificity
4 out of 5
Sensitivity
4 out of 5
Quality

Great antibody.
Rating: 4.0

  • Application Area: Western blotting

  • Sample/Target/Tissue: Thrombus
"Without digging a lot in literature I bought this antibody. And the very first western came out nicely."

Review date: 04 Dec 2018 | ASC Antibody (B-3)

Antibody Overview

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ASC Antibody (B-3)

4.0 / 5.0 | 1 reviews

Manufacturer:
Catalogue Number:
sc-514414
Antibody Type
Primary Antibody