Anti-Tyrosine Hydroxylase Antibody

4.7
/
5.0
  |  1 reviews


Product Details

Manufacturer
Cat. No.
AB152
Type
Primary Antibody
Clonality
Polyclonal
Host
Rabbit

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Description

Tyrosine hydroxylase (also know as Tyrosine 3-hydroxylase and Tyrosine 3-monooxygenase) plays an important role in the physiology of adrenergic neurons. It is the first and rate-limiting enzyme involved in the biosynthesis of the catecholamines Dopamine and Norepinephrine from tyrosine. TH is, therefore, a useful marker for dopaminergic and noradrenergic neurons. The enzymatic activity of TH requires ferrous ions as cofactors and is believed to be regulated by phosphorylation. At least four isoforms of human TH have been identified which result from alternative splicing.

Alternative Names

Tyrosine 3-hydroxylase; Tyrosine 3-monooxygenase; tyrosine hydroxylase; TH

Biological Information

Clonality Polyclonal
Host Rabbit
Reactivity Cat (Feline), Drosophila melanogaster, Ferret, Human, Mouse, Rat, Squid

Handling

Storage buffer containing liquid in 10 mM HEPES (pH 7.5), 150 mM NaCl (pH 7.5), 100 ug/mL BSA and 50% glycerol

Applications

ELISA (ELISA), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-Embedded Sections) (IHC (P)), Immunoprecipitation (IP), Western Blotting (WB)

Average Rating: 4.7
1 Scientist has reviewed this product

5 out of 5
Specificity
4 out of 5
Sensitivity
5 out of 5
Quality

A specific antibody, works well!
Rating: 4.7

  • Application Area: Immunofluorescence

  • Sample/Target/Tissue: Brain section
"The antibody works well without any unspecific signal, with a strong signal covering all the structure of dopaminergic neurons. I've used the antibody in incubation for 3 days at 4 degrees in normal donkey serum, bovine serum albumin, and 0.1% Triton-X100 to stain organotypic brain cultures of the substantia nigra. The secondary antibodies was an AlexaFluor 546 (red). No differences were observed in different lots of the antibody."

Review date: 04 Dec 2018 | Anti-Tyrosine Hydroxylase Antibody

Antibody Overview

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Anti-Tyrosine Hydroxylase Antibody

4.7 / 5.0 | 1 reviews

Manufacturer:
Catalogue Number:
AB152
Antibody Type
Primary Antibody