Strategies for the Separation and Characterization of Protein Biopharmaceuticals
Available on demand
Protein biopharmaceuticals are being developed at an explosive rate and have attracted great interest from both smaller biotech firms and big pharma. Developing protein biopharmaceuticals and their follow-on versions is highly demanding in many ways. From an analytical perspective, handling biomolecules presents new challenges for chromatographers, and the field of bio-chromatography is advancing rapidly as new and higher resolution techniques for characterizing proteins, including monoclonal antibodies, are evaluated and better understood.
In this webinar, Koen Sandra, PhD, of the Research Institute for Chromatography will discuss:
- Details of the recent analytical work his team has done to evaluate both innovator biopharmaceuticals and biosimilars.
- The initial characterization at intact protein level and subsequent aggregation, charge variant, peptide and glycan analysis.
- How this level of characterization requires multiple UHPLC and LC/MS techniques and the rationale for the selection of the different techniques and methods.
Maureen Joseph, PhD, of Agilent Technologies will also join the webinar to share some highlights of new bio-column technologies that support the techniques used.
Agilent Technologies