From Daltons to Megadaltons on a Single Mass Spectrometry Platform: UHR-qTOF for Biopharmaceuticals Analysis
Available on demand
Attend this webinar to hear about the latest advancements in ultrahigh-resolution time-of-flight mass spectrometry (UHR-qTOF MS) hardware and their applications to the analytical challenges facing innovators and biopharmaceutical/biosimilar characterization labs. Several biotech-relevant case studies will be presented to highlight: 1) The latest innovations in high-mass detection and native MS; 2) The latest advancements in resolution and mass accuracy; and 3) Advancements in electron transfer dissociation (ETD) capabilities.
You will learn:
• How a high dynamic range instrument can increase productivity by measuring small impurities on LC time scales, without the need for enrichment
• Why resolution is so important for detecting deamidation in the light and heavy chain of monoclonal antibodies
• The use of true isotopic pattern for confirming sequence variations in the light and heavy chains of monoclonal antibodies
• Why mass accuracy and ultrahigh-resolution are important for analyzing native monoclonal antibodies and antibody drug conjugates
Bruker Life Science Mass Spectrometry