ACEA Biosciences, Inc.

ACEA Biosciences is a San Diego-based biotechnology company that has identified and is developing microelectronic technology for high throughput, real time analysis of living cells to meet increasing needs for automated cell-based assays in both life science research and drug discovery. The company has developed a number of proprietary technologies for direct microelectronic detection and readout of biological assay processes. Founded in 2002, ACEA Biosciences uses it core technologies of microelectronics and cell biology to develop novel assay systems for the pharmaceutical and medical research markets.

The ACEA Biosciences RT-CES™ and RT-CIM™ systems utilize revolutionary biosensor technology for label-free, real-time monitoring of cell based assays. The core of the systems is the microelectronic cell sensor arrays integrated into the bottom of our microtiter plates which provide continuous, quantitative information about the biological status of attached cells. Any changes to cell number, size, morphology, or attachment quality will be detected in real-time without the use of reporter reagents. Proven assays include:

1. Migration/Invasion
2. Receptor activation (GPCR, RTK, etc.)
3. Adhesion
4. Compound mediated cytotoxicity
5. Cell mediated cytotoxicity (ADCC, NK, etc.)
6. Allergen Response

The integrated software allows data to be collected and saved automatically as often as every minute over virtually any time period. RT-CES is ideal for drug discovery and research applications involving cancer research, receptor/ligand interaction, cytotoxicity, apoptosis, and toxicology. Available in both 16 and 96-well multi-plate formats.

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