Pioneered by Grace Vydac and produced by a unique process based on purified organosilicate starting materials, TP silicas are well defined, high-purity, totally porous separation media that meet the most demanding needs of preparative and process scale users. Proven in over two decades of applications for protein, peptide, and nucleic acid separations, TP 300 Å reversed-phase media have excellent selectivity and reproducibility. Bulk TP-silica-based adsorbents incorporate bonded phase chemistries identical to those in VYDAC® brand analytical HPLC columns, thereby assuring economical method development and reliable, dependable scale-up for preparative and process chromatographic applications.