Viscosizer TD is unique in using Taylor Dispersion Analysis with UV area imaging in microcapillary flow to enable ultra-low volume biophysical characterization of target biomolecules in solution.
Taylor Dispersion Analysis is an inherently simple experimental method, whereby a nanoliter volume sample pulse is injected into a laminar flow of matched buffer. Analysis of the time-evolved concentration profile (or Taylorgram) from UV absorption allows the molecular diffusion coefficient and hence hydrodynamic radius of solute molecules to be determined.
Viscosizer TD uses fully automated methodology to analyze stability of small molecules, peptides and proteins, and samples with mixtures of these species, even in the presence of excipients and surfactants that can be the source of measurement interference in other techniques.
Microcapillary flow methodology also allows complementary relative viscosity measurement on the same sample using Poiseuille’s law.
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Manufacturer Malvern Panalytical | Available Worldwide
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