TRANSZYME Histone Methyltransferase Assay Kits by BellBrook Labs

No more assay development!

The Transcreener EPIGEN Methyltransferase Assay is a universal biochemical HTS assay for enzymes that produce S-adenosylhomocysteine (SAH), including all enzymes within the histone (HMTs) and DNA (DNMTs) methyltransferase families. It combines the extensively validated Transcreener AMP2/GMP2 Assay, which relies on fluorescent immunodetection of AMP, with coupling enzymes that convert SAH to AMP.

The assay provides excellent signal at low substrate conversion, with a Z' >= 0.7 and >= 100 millipolarization shift (mP) under normal reaction conditions.

• A complete solution: Kits include enzymes, substrates, and detection reagents—everything you need to detect your target histone methyltransferase (HMT)
• Eliminates HMT assay development: Pre-calibrated enzymes and substrates produce outstanding assay windows under initial velocity conditions
• Universal, HTS-ready methyltransferase assay: Transcreener® assay technology has been validated in over 5 million screening wells
• Fully scalable: Enzymes and assays available in bulk quantities and pricing