Transfluor® Cell-Based GPCR Assay Kit

Transfluor® Cell-Based GPCR Assay Kit

Molecular Devices®

Detects compound activity against known and/or orphan GPCR targets in a high content screening environment. The Transfluor® Assay is a cell-based fluorescence assay used to screen for G-protein co...read more

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Description

 

Detects compound activity against known and/or orphan GPCR targets in a high content screening environment.

The Transfluor® Assay is a cell-based fluorescence assay used to screen for G-protein coupled receptor (GPCR) ligands and other potential drugs that regulate GPCRs by deactivating or desensitizing a common pathway. By attaching a fluorescent label to beta-arrestin, the location of the receptor-arrestin complex may be monitored during receptor activation. Since desensitization only occurs with an activated receptor, monitoring beta-arrestin translocation and subsequent receptor recycling provides a method to detect the activation of any GPCR.

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