Thermo Scientific LTQ Orbitrap XL by Thermo Fisher Scientific
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Status:
Advanced Reviewer
Member since: 2017
Organization: cvrl
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- Ease of use
- After sales service
- Value for money
Great sensitivity and reproducible results in ppm/ ppb levels
Application Area: drug & metabolites in body fluids
"The Orbitrap is an ion trap mass analyzer that consists of two outer electrodes and a central electrode, which enable it to act as both an analyzer and detector. With a QTOF you are already in a range of mass accuracy of about 1-2 ppm and a resolution R = 30000 to 50000. Orbitraps have a mass accuracy in the sub-ppm range and are even better in resolution. Unlike in ion traps and QMFs that require a voltage ramp to detect different m/z's sequentially, in the Orbitrap all m/z's are detected simultaneously. Within the Orbitrap the frequency of ion oscillation in the time domain is measured, with all m/z species measured simultaneously Enabled to detect thousands of semi volatile and non-volatile, high-molecular-weight bio-oil compounds and provided partial information about their structure."
Review date: 25 Sep 2023 | Thermo Scientific LTQ Orbitrap XL
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Reviewer Member since: 2017
Organization: SUNY Buffalo
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- Ease of use
- After sales service
- Value for money
Great results. Very consistent system.
Application Area:Proteomics
"Simple to use VERY flexible system. Can do small molecules as well as proteomics"
Review date: 03 Feb 2023 | Thermo Scientific LTQ Orbitrap XL
Status:
Advanced Reviewer Member since: 2018
Organization: Komvux
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- Ease of use
- After sales service
- Value for money
Good quality and reproductivity.
Application Area:Proteomics
"Nice operation experience and easy hand-on practice."
Review date: 10 Mar 2022 | Thermo Scientific LTQ Orbitrap XL
Status:
Advanced Reviewer Member since: 2018
Organization: Komvux
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- Ease of use
- After sales service
- Value for money
Super MS device and can’t obtain good results without it!
Application Area:Phosphoproteomic analysis
"The instrumental effectiveness has been shown quite well during the past years’ practical application and test work. The satisfactory analytical results’ reproducibility has also been achieved most of the time. The instrument is relatively easy to control even for beginners and it’s a good choice in terms of performance/cost ratio and maintenance service as well."
Review date: 16 Apr 2021 | Thermo Scientific LTQ Orbitrap XL
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Reviewer Member since: 2020
Organization: Fraunhofer Institute (IME)
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- Ease of use
- After sales service
- Value for money
Application Area:Pesticides, food, and environmental analysis
"Long life, reliable and stable instrument for qualification (MSn) and quantification."
Review date: 10 Feb 2020 | Thermo Scientific LTQ Orbitrap XL
Status:
Advanced Reviewer Member since: 2019
Organization: Case Western Reserve University
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- Ease of use
- After sales service
- Value for money
Perfect MS instrument for protein characterization.
Application Area:Hydrogen deuterium exchange and hydroxyl radical footprinting
"This is my first MS instrument and I really liked it. This instrument is so robust and easy to work with. I have used it for hydrogen/deuterium exchange and hydroxyl radical foot-printing experiments. It gives reprodicible results with good signal and minimum sample requirement."
Review date: 16 Dec 2019 | Thermo Scientific LTQ Orbitrap XL
Status:
Advanced Reviewer Member since: 2019
Organization: Access Medical Laboratories
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- Ease of use
- After sales service
- Value for money
Exceptional.
Application Area:Small molecules
"Exceptional performance, exceptional training programs by Thermo Scientific."
Review date: 21 Nov 2019 | Thermo Scientific LTQ Orbitrap XL
Status:
Reviewer Member since: 2019
Organization: The University Of Kansas
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- Ease of use
- After sales service
- Value for money
Relatively easy to interface with home build CE.
Application Area:Mass spectrometric analysis of peptides
"We use Thermo Fisher LTQ XL system for analysis of small peptides. The MS is bit old but still works well."
Review date: 26 Mar 2019 | Thermo Scientific LTQ Orbitrap XL
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Reviewer Member since: 2019
Organization: Texas Tech University
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- Ease of use
- After sales service
- Value for money
Powerful instrument.
Application Area:Analysis of biological macromolecules such as proteins and glycans.
"It is one of the powerful mass spctrometers and met most of our requirment for research. The after sale services is also professional and efficient."
Review date: 26 Mar 2019 | Thermo Scientific LTQ Orbitrap XL
Status:
Reviewer Member since: 2019
Organization: University Of Naples
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- Ease of use
- After sales service
- Value for money
My favorite instrument in lab.
Application Area:Proteomics
"The instrument enables high quality results with high sensitivity and accuracy in mass spectrometry-based identification of proteins in complex mixtures."
Review date: 18 Feb 2019 | Thermo Scientific LTQ Orbitrap XL
Status:
Advanced Reviewer Member since: 2015
Organization: Xen Biofluidx
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- Ease of use
- After sales service
- Value for money
A must-have lab instrument in processes involving high yield purification.
Application Area:Intermediate and final product purification
"The equipment is absolutely instrumental in our lab processes in consistently providing good yield and purity level."
Review date: 05 Aug 2018 | Thermo Scientific LTQ Orbitrap XL
Status:
Advanced Reviewer Member since: 2015
Organization: Xen Biofluidx
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- Ease of use
- After sales service
- Value for money
A ubiquitous tool like the pH meter and balance
Application Area:Purification of intermediates and final products
"A great and indispensable lab tool that confers great and consistent yield and high purity."
Review date: 26 Jul 2018 | Thermo Scientific LTQ Orbitrap XL
Status:
Advanced Reviewer Member since: 2015
Organization: Xen Biofluidx
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- Ease of use
- After sales service
- Value for money
I cannot live without this lab tool. It's like a pH meter.
Application Area:Purification of intermediates and final products.
"Great yield and purity of intermediates and final products."
Review date: 22 Jul 2018 | Thermo Scientific LTQ Orbitrap XL
Status:
Advanced Reviewer Member since: 2015
Organization: Xen Biofluidx
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- Ease of use
- After sales service
- Value for money
An indispensable lab tool.
Application Area:Purification
"Effective tool to use to purify intermediates and final products with good yield and level of purity."
Review date: 24 Mar 2018 | Thermo Scientific LTQ Orbitrap XL
Status:
Advanced Reviewer Member since: 2015
Organization: Xen Biofluidx
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- Ease of use
- After sales service
- Value for money
Very Reliable and Effective Means of Purification.
Application Area:Product/intermediate purification
"Good yield with exceedingly high desired product purity."
Review date: 13 Mar 2018 | Thermo Scientific LTQ Orbitrap XL
Status:
Reviewer Member since: 2013
Organization: Mallinckrodt Pharmaceuticals
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- Ease of use
- After sales service
- Value for money
Excellent instrument for structure elucidation.
Application Area:Unknown Identification in pharmaceuticals (impurities, degradants, contaminants)
"This instrument is very easy to use and gives incredible mass accuracy, which makes obtaining formulae for both precursor and product (MSn) ions fairly easy. The MSn capability does add the ability to acquire a great deal of data to help in the structure elucidation, although considerable expertise is needed to interpret the data. The sensitivity of the instrument is very good in general, although it may be a little less than some other instruments on the very small molecule end. I would highly recommend this instrument!"
Review date: 18 Aug 2016 | Thermo Scientific LTQ Orbitrap XL
Status:
Reviewer Member since: 2016
Organization: Imperial College London
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- Ease of use
- After sales service
- Value for money
Great for quantitative proteomics good workhorse instrument good software
Application Area:proteomics
"Use this instrument to identify and quantitate protein from complex samples, also used it to identify phosphorylation sites in cancer cell lines. Resolution and accuracy make it suitable of this kind of work! "
Review date: 27 Jun 2016 | Thermo Scientific LTQ Orbitrap XL
Status:
Expert Reviewer Member since: 2016
Organization: Eastern Virginia Medical School
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- Ease of use
- After sales service
- Value for money
Quality instrument
Application Area:Proteomic analysis of biological fluids
"We use this MS for the majority of our proteomics work. It has been a workhorse machine."
Review date: 03 Jun 2016 | Thermo Scientific LTQ Orbitrap XL
Status:
Reviewer Member since: 2015
Organization: University of Oklahoma
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- Ease of use
- After sales service
- Value for money
I really enjoy using this instrument
"I really enjoy using this instrument, and even though we bought it from Thermo as a refurbished instrument, it has been working pretty well for the past 5 years."
Review date: 11 Nov 2015 | Thermo Scientific LTQ Orbitrap XL
Status:
Reviewer Member since: 2013
Organization: Dr.Reddys Ltd
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- Ease of use
- After sales service
- Value for money
Application Area:Biopharmaceuticals
"It is one of the best iontrap instrument I have ever used. It delivers the best MS and MS/MS result for protein identification and characterization. The sensitivity and mass accuracy is very good. it makes impurity characterization at the ease, very rugged instrument too. It is best suitable for biopharmaceutical applications."
Review date: 06 Oct 2015 | Thermo Scientific LTQ Orbitrap XL
Status:
Reviewer Member since: 2006
Organization: University of Missouri
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- Ease of use
- After sales service
- Value for money
Application Area:Proteomics
"Generates lots of good data with relatively modest file sizes. User interface is easy to use. Accurate mass is great."
Review date: 23 Mar 2012 | Thermo Scientific LTQ Orbitrap XL
Status:
Reviewer Member since: 2011
Organization: Unviersite Catholique de Louvain
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- Ease of use
- After sales service
- Value for money
"Very fast instrument."
Review date: 31 Aug 2011 | Thermo Scientific LTQ Orbitrap XL
Status:
Reviewer Member since: 2011
Organization: UFZ
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- Ease of use
- After sales service
- Value for money
"We have software problems which occur quite often. Measurement is very good but can take a long time to repair."
Review date: 22 Aug 2011 | Thermo Scientific LTQ Orbitrap XL
Status:
Reviewer Member since: 2007
Organization: Bristol-Myers Squibb
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- Ease of use
- After sales service
- Value for money
"Nice user interface, some instabilities in software. Easy to calibrate in time."
Review date: 04 Feb 2011 | Thermo Scientific LTQ Orbitrap XL
Status:
Reviewer Member since: 2009
Organization: Merck
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- Ease of use
- After sales service
- Value for money
Review date: 01 Jul 2009 | Thermo Scientific LTQ Orbitrap XL
Status:
Reviewer Member since: 2004
Organization: Mass Spectrometry Centre University of Firenze
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- Ease of use
- After sales service
- Value for money
Review date: 18 May 2009 | Thermo Scientific LTQ Orbitrap XL
Status:
Reviewer Member since: 2006
Organization: Covance
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- Ease of use
- After sales service
- Value for money
Review date: 16 Apr 2009 | Thermo Scientific LTQ Orbitrap XL
Status:
Reviewer Member since: 2008
Organization: University Of Zurich
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- Ease of use
- After sales service
- Value for money
Review date: 11 Sep 2008 | Thermo Scientific LTQ Orbitrap XL
The Thermo Scientific LTQ Orbitrap XL hybrid FTMS (Fourier Transform Mass Spectrometer) supports a wide range of applications from routine compound identification to the most challenging analysis of low level components in complex mixtures. The LTQ Orbitrap XL is based on the fast and highly sensitive Thermo Scientific LTQ XL linear ion trap and the patented Orbitrap* technology. The LTQ Orbitrap XL features a new HCD collision cell for ultimate flexibility in fragmentation experiments for advanced proteomics and small molecule research.
Key features of the Thermo Orbitrap XL include:
Outstanding Mass Accuracy, Resolution, Dynamic Range and Sensitivity
• Featuring the new HCD collision cell for ultimate flexibility in fragmentation experiments for advanced proteomics and small molecule research
• Superior mass accuracy for lower false positive rates (FPRs)
• Parallel acquisition mode for optimized productivity
From Protein ID to Biomarker Discovery with the Thermo LTQ Orbitrap
• Excellent sensitivity and fragmentation efficiency
• Reliable identification and quantitation in one experiment
High quality data from the LTQ Orbitrap XL for reliable de novo sequencing
• Superior mass accuracy and high resolution leading to confident de novo sequencing results
• Multiple collision modes (CID and HCD) for comprehensive structural information
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