Thermo Scientific Exactive Plus Orbitrap LC-MS by Thermo Fisher Scientific

4.4
/
5.0
  |  20 reviews
The Exactive Plus Orbitrap LC-MS is a benchtop full scan mass spectrometer designed for compound identification and high-throughput, high-performance screening. The Exactive Plus delivers high resolution accurate mass (HRAM) data and fast, reproducible results for qualitative and quantitative analysis. The availability of HRAM and full scan capability gives you all the data, all the time. It allows retrospective data analysis and eliminates MS method development leading to improved and simplifi... Read more


Thermo Scientific Exactive Plus Orbitrap LC-MS by Thermo Fisher Scientific product image
Thermo Scientific Exactive Plus Orbitrap LC-MS

The supplier does not provide quotations for this particular product through SelectScience. You can search for similar products in our product directory.




Average Rating: 4.4
20 Scientists have reviewed this product

5 out of 5
Ease of use
4 out of 5
After sales service
4 out of 5
Value for money


  • Status:

    Reviewer
  • Member since: 2018

  • Organization: CannaSoul Analytics



  • Ease of use
    4 out of 5
    After sales service
    4 out of 5
    Value for money
    5 out of 5
Share this Review on LinkedinShare this Review on TwitterShare this Review on Facebook
One of the best instrument for unknown analysis for metabolomics and proteomics
Rating: 4.3

  • Application Area: Metabolomics

"High quality LCMS, easy to use and can be apply for unknown identification and also quantification"

Review date: 27 Mar 2023 | Thermo Scientific Exactive Plus Orbitrap LC-MS
  • Status:

    Advanced Reviewer

  • Member since: 2012

  • Organization: Sandor Proteomics pvt ltd



  • Ease of use
    4 out of 5
    After sales service
    3 out of 5
    Value for money
    4 out of 5
Share this ReviewShare this Review on TwitterShare this Review
Great results
Rating: 3.7

  • Application Area:Metabolomics

"Easy to use"

Review date: 22 Oct 2022 | Thermo Scientific Exactive Plus Orbitrap LC-MS
  • Status:

    Reviewer

  • Member since: 2021

  • Organization: ExoNox Biosciences



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
Share this ReviewShare this Review on TwitterShare this Review
Quality instrument for high quality data
Rating: 5.0

  • Application Area:Analyze exosome protein profile

"Gain quality results without too many glitches, less chance to get clotted, consistent results, and quick service wait time"

Review date: 28 Sep 2022 | Thermo Scientific Exactive Plus Orbitrap LC-MS
  • Status:

    Reviewer

  • Member since: 2022

  • Organization: OSU



  • Ease of use
    5 out of 5
    After sales service
    3 out of 5
    Value for money
    5 out of 5
Share this ReviewShare this Review on TwitterShare this Review
Lot of applications and easy to use software
Rating: 4.3

  • Application Area:Dereplication of plant metabolites

"Xcalibur software is very easy to use. A lot of resources for learning how to use it is free and a lot of applications from a lot of labs have been developed. Raw data ready to use with free softwares for their analysis"

Review date: 28 Sep 2022 | Thermo Scientific Exactive Plus Orbitrap LC-MS
  • Status:

    Reviewer

  • Member since: 2021

  • Organization: università degli studi di palermo



  • Ease of use
    5 out of 5
    After sales service
    4 out of 5
    Value for money
    3 out of 5
Share this ReviewShare this Review on TwitterShare this Review
Great results
Rating: 4.0

  • Application Area:Drugs

"Excellent"

Review date: 17 Jul 2022 | Thermo Scientific Exactive Plus Orbitrap LC-MS
  • Status:

    Reviewer

  • Member since: 2019

  • Organization: Faculty Of Pharmacy, Beni-Suef University



  • Ease of use
    5 out of 5
    After sales service
    4 out of 5
    Value for money
    5 out of 5
Share this ReviewShare this Review on TwitterShare this Review
I like it
Rating: 4.7

  • Application Area:Natural products discovery

"I like working on LC-HRMS from Thermo Fischer Scientific"

Review date: 21 Jan 2022 | Thermo Scientific Exactive Plus Orbitrap LC-MS
  • Status:

    Reviewer

  • Member since: 2020

  • Organization: Osmania University



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
Share this ReviewShare this Review on TwitterShare this Review
The best ultra-high-resolution table top mass spectrometer!
Rating: 5.0

  • Application Area:metabolomics

"In my opinion, this is the only best ultra-high-resolution table top mass spectrometer. Further, the software provided by Thermo makes the instrument easy to operate."

Review date: 22 Dec 2021 | Thermo Scientific Exactive Plus Orbitrap LC-MS
  • Status:

    Reviewer

  • Member since: 2020

  • Organization: Central Veterinary Research Laboratory



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
Share this ReviewShare this Review on TwitterShare this Review
Great product.
Rating: 5.0

  • Application Area:Forensic toxicology

"Great product, Accurate."

Review date: 25 Jul 2021 | Thermo Scientific Exactive Plus Orbitrap LC-MS
  • Status:

    Reviewer

  • Member since: 2020

  • Organization: Lotus Pharmaceutical Co LTD



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    4 out of 5
Share this ReviewShare this Review on TwitterShare this Review
Great technology.
Rating: 4.7

  • Application Area:Drug Analysisa

"Great technology, good reproducible results."

Review date: 24 Jul 2021 | Thermo Scientific Exactive Plus Orbitrap LC-MS
  • Status:

    Reviewer

  • Member since: 2020

  • Organization: Cincinnati Children's Hospital



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
Share this ReviewShare this Review on TwitterShare this Review
Best mass spec on the market.
Rating: 5.0

  • Application Area:Metabolomics and lipidomics

"Most reliable mass spectrometry instrument. The mass accuracy provided is a must when used for metabolomics and lipidomics. Customer service is outstanding."

Review date: 16 Jul 2021 | Thermo Scientific Exactive Plus Orbitrap LC-MS


  • Status:

    Advanced Reviewer

  • Member since: 2020

  • Organization: University of Gujrat, Hafiz Hayat Campus, 50700,



  • Ease of use
    5 out of 5
    After sales service
    4 out of 5
    Value for money
    5 out of 5
Share this ReviewShare this Review on TwitterShare this Review
Highly recommended, great results
Rating: 4.7

  • Application Area:Analyzing heavy metal contents

"It is a very friendly and easy to use device. It is very cost effective and highly precise instrument for your lab."

Review date: 12 Apr 2021 | Thermo Scientific Exactive Plus Orbitrap LC-MS
  • Status:

    Reviewer

  • Member since: 2016

  • Organization: EPA



  • Ease of use
    4 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
Share this ReviewShare this Review on TwitterShare this Review
Works as advertised!
Rating: 4.7

  • Application Area:Environmental forensics

"This instrument works as advertised and is reliable for accurate mass measurement. The Orbitrap technology works far better for us than does Q-Tof. These instruments are also very reliable and hold a mass calibration well as they are not so sensitive to temperature variations in the laboratory. The software makes creating complex instrument methods possible, yet intuitive. This gives us the flexibility to create methods for our specialized needs without a lot of time involved learning difficult software."

Review date: 10 Nov 2020 | Thermo Scientific Exactive Plus Orbitrap LC-MS
  • Status:

    Advanced Reviewer

  • Member since: 2012

  • Organization: Sandor Proteomics pvt ltd



  • Ease of use
    5 out of 5
    After sales service
    4 out of 5
    Value for money
    4 out of 5
Share this ReviewShare this Review on TwitterShare this Review
Really awesome to work with great technology
Rating: 4.3

  • Application Area:Proteomics

"Orbitrap is the new emerging technology in mass spectrometry and produces great proteomics data that is helpful in emerging new research fields."

Review date: 22 Jun 2019 | Thermo Scientific Exactive Plus Orbitrap LC-MS
  • Status:

    Reviewer

  • Member since: 2019

  • Organization: University Of Dhaka



  • Ease of use
    5 out of 5
    After sales service
    4 out of 5
    Value for money
    4 out of 5
Share this ReviewShare this Review on TwitterShare this Review
Best instrument in proteomcis.
Rating: 4.3

  • Application Area:Proteomics in tissues and cell lines

"The instrument is very effective. Researchers who want to explore global unbiased proteomics analysis instead of targeted approach will love the flexibility and user-friendliness of this product. LC-MS/MS measurements are not trivial and require specialized expertise. However Exactive instruments are the best that a user can hope for in proteomics research. Its wide range of applications is second to none."

Review date: 18 Jun 2019 | Thermo Scientific Exactive Plus Orbitrap LC-MS
  • Status:

    Reviewer

  • Member since: 2019

  • Organization: University Of Strasbourg



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
Share this ReviewShare this Review on TwitterShare this Review
Great results, robust instrument.
Rating: 5.0

  • Application Area:Proteomics

"High quality and reproducible results for proteomics application. Easy to use even with different users on the same instrument."

Review date: 18 Jun 2019 | Thermo Scientific Exactive Plus Orbitrap LC-MS
  • Status:

    Reviewer

  • Member since: 2019

  • Organization: Avans Hogeschool



  • Ease of use
    4 out of 5
    After sales service
    3 out of 5
    Value for money
    4 out of 5
Share this ReviewShare this Review on TwitterShare this Review
Good instrument for untargeted approaches .
Rating: 3.7

  • Application Area:Forensic toxicology

"The instrument is fairly easy to get to know and work with! It gives good specificity and we have been able to use it for untargeted metabolomic approaches! However, the sensitivity is not as good as promised and because it is linked to an LC from a different company, there are some bugs in the system once in a while!"

Review date: 04 Jun 2019 | Thermo Scientific Exactive Plus Orbitrap LC-MS
  • Status:

    Advanced Reviewer

  • Member since: 2015

  • Organization: CDPH



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
Share this ReviewShare this Review on TwitterShare this Review
Still is in project research finding.
Rating: 5.0

  • Application Area:unknow screening

"very sensitive and accurate easy to be use great software and tech services supports excellent instrument operative training and services"

Review date: 23 Jun 2016 | Thermo Scientific Exactive Plus Orbitrap LC-MS
  • Status:

    Reviewer

  • Member since: 2013

  • Organization: Universitat Rovira i Virgili



  • Ease of use
    5 out of 5
    After sales service
    4 out of 5
    Value for money
    2 out of 5
Share this ReviewShare this Review on TwitterShare this Review
Rating: 3.7

  • Application Area:environmental analysis

"This mass analyzer is easy to use and does not need heavy optimization of source or mass spectrometric features. Provides more structural information and also provides post analysis information. The mass accuracy is excellent and the reproducibility is also good."

Review date: 27 Aug 2013 | Thermo Scientific Exactive Plus Orbitrap LC-MS
  • Status:

    Reviewer

  • Member since: 2013

  • Organization: Dalian Institute of Chemical Physics



  • Ease of use
    1 out of 5
    After sales service
    4 out of 5
    Value for money
    4 out of 5
Share this ReviewShare this Review on TwitterShare this Review
Rating: 3.0

  • Application Area:proteomics

"Good for large-scale analysis of proteomics and very fast scan speed. It is also good for glycoproteomics and for glycan structure but only HCD is allowed."

Review date: 07 Aug 2013 | Thermo Scientific Exactive Plus Orbitrap LC-MS
  • Status:

    Reviewer

  • Member since: 2013

  • Organization: University of Tennessee



  • Ease of use
    4 out of 5
    After sales service
    5 out of 5
    Value for money
    4 out of 5
Share this ReviewShare this Review on TwitterShare this Review
Rating: 4.3

  • Application Area:lipidomics

"The system is easy to use in various analytical applications, but the mass spec software needs more time to be familiar with. The MS has perfect resolution. The service engineers were really helpful and skilled. However, the price is really high."

Review date: 28 May 2013 | Thermo Scientific Exactive Plus Orbitrap LC-MS
The Exactive Plus Orbitrap LC-MS is a benchtop full scan mass spectrometer designed for compound identification and high-throughput, high-performance screening.

The Exactive Plus delivers high resolution accurate mass (HRAM) data and fast, reproducible results for qualitative and quantitative analysis.

The availability of HRAM and full scan capability gives you all the data, all the time. It allows retrospective data analysis and eliminates MS method development leading to improved and simplified analytical throughput.

Exactive Plus is easy-to-use, cost effective to operate and coupled with workflow-driven software, makes an ideal instrument for new users in routine analytical laboratories.


Selected benefits of the Exactive Plus are specified below:

  • High Resolving Power
  • (up to 140,000) - Eliminates isobaric interferences to increase confidence for analysis or complex samples
  • Mass accuracy - Better than 1ppm in full scan and AIF scan using fully automated AGC and mass calibration procedures offers confident identification
  • U-HPLC Scan Speed - The 12Hz scanning frequency of Exactive Plus is fully compatible with U-HPLC and ensures exact mass measurement for fast chromatography applications
  • Fast Polarity Switching - A full cycle of 1 positive and 1 negative scan is performed within 1 second at a resolution setting of 35,000 without sacrificing mass accuracy
  • All-Ion-Fragmentation (AIF) - With multiple dissociation techniques; in source collisional induced dissociation (CID) and high energy collisional dissociation (HCD), provides MS and MS/MS data
  • Full MS scan, AIF scan, data dependent AIF, alternating Full MS and AIF scan
  • Intuitive software interface

The Exactive Plus Orbitrap LC-MS is ideal for the following applications:

  • Environmental and Food Safety
  • Clinical Research
  • Forensic Toxicology
  • Drug discovery, metabolism and pharmacokinetics (DMPK)
  • Metabolomics
  • Pharmaceutical
  • BioPharma – Intact Protein analysis

Laboratories analyzing food, pharmaceuticals, neutraceuticals, and other complex samples can now purchase Exactive Plus LC-MS system equipped from the factory with IonSense ID-CUBE™ ion sources. This configuration is designed to minimize the need for sample preparation to simplify and speed analyses.

Product Overview

Thermo Scientific Exactive Plus Orbitrap LC-MS by Thermo Fisher Scientific product image

Thermo Scientific Exactive Plus Orbitrap LC-MS

Manufacturer Thermo Fisher Scientific

4.4 / 5.0 | 20 reviews