As the first in a series of new LC/MS kits, the ClinSpec Immunosuppressants Test provides a quick out-of-the-box solution for the monitoring of immunosuppressant drugs during clinical research. The kit enables standardization of LC/MS results from different laboratories, independent of location, and allows laboratories with limited technical staff to perform routine LC/MS analysis. While the test kit is optimized for use on Thermo Scientific TSQ Quantum Ultra and Exactive LC/MS systems, the application can be used on other LC/MS platforms as well.
The Thermo Fisher Scientific ClinSpec Immunosuppressant Test Kit includes the following, liquid stable, ready-to-use materials:
• Six-level Calibrators - 6 bottles (1.5 mL each level) containing Cyclosporine, Everolimus,
Sirolimus and Tacrolimus at concentrations ranging between 10-2000 ng/mL (Cyclosporine A) and 1-50 ng/mL (Everolimus, Sirolimus and Tacrolimus)
• Tri-level Controls - 2 bottles per level (3 mL each), containing Cyclosporine, Everolimus,
Sirolimus and Tacrolimus at concentrations 30, 125 & 375 ng/mL (Cyclosporine A) and 3, 12 & 30 ng/mL (Everolimus, Sirolimus and Tacrolimus)
• Cyclosporine High Controls - 3 bottles per level (3 mL each) of concentrations 750ng/mL and 1500ng/mL
• Internal Standard -2 Ampules (1.0 mL each), Ascomycin for Tacrolimus, Sirolimus & Everolimus, and Cyclosporine D for Cyclosporine A
• Blank Solution - 6 bottles (1.5mL each) of whole blood matrix negative for Tacrolimus, Sirolimus,
Everolimus, and Cyclosporine A
• 50 mL Extraction Reagent
• 2 HPLC Columns
Manufacturer Thermo Fisher Scientific
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