Tecan’s patented GCM was a breakthrough for cell-based experiments, offering precise regulation of oxygen and carbon dioxide levels within the reader’s detection chamber for the first time. This powerful module is now fully integrated into the new Spark® multimode reader, providing rigorous environmental control for an even wider range of cell biology applications.
The integrated GCM uses improved sensor technology to increase measurement accuracy and minimize cross-interference for oxygen measurements. Combined with redesigned, independent gas inlets, this offers precise, independent control of both O2 and CO2 levels within the reader chamber, helping to further stabilize culture conditions for more consistent cell growth. The greater sensitivity and precision offered by this set-up also allows the instrument to automatically compensate for variations in the atmospheric partial pressure of CO2 using the module’s unique altitude correction function, which is accessed via an intuitive new interface in the SparkControl™ software.
Process security has also been enhanced, providing rapid detection of changes in gas pressure or flow to identify if the target concentration will not be reached or deviates significantly during incubation, with both audible and visible warnings to alert the user. These improved features ensure greater biological relevance for a wide range of studies, extending the experimental window for microplate-based investigations of anaerobic or facultative anaerobic bacteria, and allowing close replication of hypoxic or physiological conditions for eukaryotic cells. Together with the Spark´s cell biology oriented functions – including Optimal Cell Reading, linear and orbital shaking, advanced temperature control with the Te-Cool™ module, cell confluence measurements and automated z-focusing – this comprehensive solution sets new standards for cell-based assays.
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