The Optimum Bed Density (OBD™) design preparative columns are the culmination of a two year research and development project aimed at delivering the most reliable and consistent preparative column performance. This innovative manufacturing procedure combines the influences of hardware, particle characteristics and packed bed densities, resulting in columns with excellent stability, superior reproducibility and extremely high efficiencies.
Loadability by Design Successful scale-up of an isolation and purification process is not only a function of column efficiency, but is also related to the loadability of the chromatographic material. The physical characteristics of preparative phases, such as surface area and ligand density, do not always correlate well with the mass loadability of ionizable compounds. SunFire™ Prep silica particles have been synthetically designed under cGMP protocols to deliver maximum loadability in acidic to moderate pH mobile phase conditions.
Efficiency and Scalability The isolation and purification of critical compound pairs is a major challenge to purification scientists. Often a successful analytical separation will not scale up directly due to the reduced performance of the preparative column. The OBD™ design in combination with the efficient SunFire™ particles ensures equivalent chromatographic performance from analytical to preparative dimensions, eliminating the need for any subsequent time consuming method redevelopment.