SDR HyperD® Solvent-detergent Removal Chromatography Sorbent by Pall Life Sciences Products - Biopharmaceutical Division
Solvent-detergent Removal Chromatography Sorbent • Binds solvent and detergent molecules used in viral inactivation processes (TnBP and Triton® X-100) • High recovery for proteins (exclusion limit 10 kDa) • High sorption capacity for small hydrophobic molecules • Stable in acid, polar organic and oxidizing solutions Plasma preparations may contain viruses that are effectively removed and inactivated by combining nanofiltration (for size exclusion removal of non-lipid enveloped viruses) and treat... Read more
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SDR HyperD® Solvent-detergent Removal Chromatography Sorbent
Solvent-detergent Removal Chromatography Sorbent
• Binds solvent and detergent molecules used in viral inactivation processes (TnBP and Triton® X-100)
• High recovery for proteins (exclusion limit 10 kDa)
• High sorption capacity for small hydrophobic molecules
• Stable in acid, polar organic and oxidizing solutions
Plasma preparations may contain viruses that are effectively removed and inactivated by combining nanofiltration (for size exclusion removal of non-lipid enveloped viruses) and treatment with non-ionic solvents and detergents (effective for lipid-coated viruses).
The elimination of solvent and detergent from biological fractions is necessary, and can be achieved by various methods including sorbent partitioning, size exclusion, affinity or batch extraction with vegetable oils combined to reverse phase on C18. SDR HyperD® is a unique sorbent designed to eliminate solvent and detergent from biological fluids.
Product Description and Mechanism of Solvent Detergent Adsorption.
SDR HyperD is a composite sorbent that combines a silica-bead moiety filled with a three-dimensional cross-linked hydrophobic polymer. The particle size distribution (40-100 µm), the small pore size of the silica beads and the nature of the polymer have been optimized for a retention of solvents and detergents typically used in viral inactivation processes (i.e. Tri-n-Butyl Phosphate – TnBP – and Triton® X-100).
The adsorption mechanism involves both the silica moiety and the hydrophobic polymer. The adsorption of Triton X-100 is proportional to the silica surface area, whereas the adsorption of TnBP is linked to binding to the organic polymer moiety. The main features of SDR HyperD sorbent are summarized in Table I and the adsorption mechanism represented in Figure 1.
• Binds solvent and detergent molecules used in viral inactivation processes (TnBP and Triton® X-100)
• High recovery for proteins (exclusion limit 10 kDa)
• High sorption capacity for small hydrophobic molecules
• Stable in acid, polar organic and oxidizing solutions
Plasma preparations may contain viruses that are effectively removed and inactivated by combining nanofiltration (for size exclusion removal of non-lipid enveloped viruses) and treatment with non-ionic solvents and detergents (effective for lipid-coated viruses).
The elimination of solvent and detergent from biological fractions is necessary, and can be achieved by various methods including sorbent partitioning, size exclusion, affinity or batch extraction with vegetable oils combined to reverse phase on C18. SDR HyperD® is a unique sorbent designed to eliminate solvent and detergent from biological fluids.
Product Description and Mechanism of Solvent Detergent Adsorption.
SDR HyperD is a composite sorbent that combines a silica-bead moiety filled with a three-dimensional cross-linked hydrophobic polymer. The particle size distribution (40-100 µm), the small pore size of the silica beads and the nature of the polymer have been optimized for a retention of solvents and detergents typically used in viral inactivation processes (i.e. Tri-n-Butyl Phosphate – TnBP – and Triton® X-100).
The adsorption mechanism involves both the silica moiety and the hydrophobic polymer. The adsorption of Triton X-100 is proportional to the silica surface area, whereas the adsorption of TnBP is linked to binding to the organic polymer moiety. The main features of SDR HyperD sorbent are summarized in Table I and the adsorption mechanism represented in Figure 1.
Product Overview
SDR HyperD® Solvent-detergent Removal Chromatography Sorbent
Manufacturer Pall Life Sciences Products - Biopharmaceutical Division
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