The ability of Enamine to synthesize a large number of screening compounds is formulated as its REAL DataBase. This original product represents a validated chemistry space that was created through the rigorous selection of reactions and the appropriate building blocks in numerous tests. We have optimized over 30 liquid-phase reactions to give individual products with over 80% success in sufficient purity (>90%). Currently our REAL DataBase contains over 1·10⁷ structures with at least 50% success rate of synthesis.