Radleys Lollipop Phase Separator™ by Radleys

The Lollipop Phase Separator provides an effective and economic alternative to the use of expensive robotic sample handlers for purification after synthesis, using phase separation.

The principle of the Lollipop Phase Separator is based on the rapid freezing of the aqueous phase in a two phase mixture, post synthesis, within either a 96 array of 1.2ml tubes or 24 array of 7ml pots. Using chemically resistant peek pins in a micro titer plate format, the aqueous phase freezes to the pins, forming frozen ‘lollipops’, allowing for their total separation from the organic liquid phase.

• The Lollipop Phase Separator can be used with both organic phases that are more dense (i.e. chloroform) or less dense (i.e. ethyl acetate)than aqueous.

• The Lollipop purification procedure may be repeated up to 3 times: with an aqueous acid, aqueous base and a neutral aqueous phase if the chemistry requires.

• Ideal volumes for the 1.2ml x 96 array are 300µl organic phase and 300µl aqueous phase per tube.

• Ideal volumes for the 7ml x 24 array are 2ml organic phase and 2ml aqueous phase per pot.

 The Lollipop is designed to optimise integration with standard 96 or 24 well MTP formats. This greatly speeds up the transfer of samples between synthesis, separation, purification and evaporation stages.