R&D Systems now offers a Quantikine ELISA Kit for measuring high molecular weight (HMW) Adiponectin/Acrp30 in serum or plasma. This is the first commercially available ELISA designed to measure HMW Adiponectin without the need for proteolytic pretreatment of the sample. HMW Adiponectin is the primary bioactive form with insulin-sensitizing activity. Its circulating levels negatively correlate with obesity, insulin resistance, and coronary artery disease. The Human HMW Adiponectin/Acrp30 Kit utilizes antibodies that have been rigorously tested to ensure specificity for the HMW isoform.