The Stable Alternative to C8 or C18 Columns Hamilton PRP-1 (Polymeric Reversed Phase) HPLC columns combine the best characteristics of silica-based and polymeric columns to arrive at a column that is highly inert and long-lasting. Quality assurance as well as research and development laboratories find that PRP-1 columns last significantly longer than silica-based C8 or C18 columns. This is particularly true for difficult analyses like: high pH samples (pH 8-13); labile or reactive samples (irreversible adsorption); high aqueous purifications (80-100% water); and separations with ion pairing reagents.
PRP-1 Columns are beneficial in a number of ways:
Wide pH Stability Stability from pH 1 to 13 allows for the analysis of samples at high pH (8-13) without the possibility of column degradation or loss of efficiency. An expanded pH range also allows samples to be chromatographed while ionized. This greatly enhances the detectability of some samples.