Robust, quantitative detection of aggresomes relevant to the study of neurodegenerative disease, liver disease and toxicology:
Certain cellular inclusion bodies associated with human disease are thought to arise from an aggresomal response including Alzheimer’s disease as it relates to intracellular and extracellular aggregates, Lewy bodies associated with neurons in Parkinson's disease, Mallory bodies associated with liver cells in alcoholic liver disease and Hyaline inclusion bodies associated with astrocytes in amyotrophic lateral sclerosis (ALS).
ProteoStat® Aggresome Detection kit provides a rapid, specific and quantitative approach to identify inhibitors relevant to neurodegenerative disease in an authentic cellular context.
This fixed-cell assay doesn’t require non-physiological protein mutations or genetically engineered cell lines. ProteoStat® dye has been validated under a wide range of conditions and with small molecule modulators, demonstrating suitability for screening compounds of potential therapeutic value, and optimized for antibody co-localization studies to identify interactions between aggregated protein cargo and the various proteins implicated in autophagy and aggresome formation.