ProSense 680 Fluorescent Imaging Agent by PerkinElmer, Inc.

ProSense 680 is a protease activatable fluorescent in vivo imaging agent that is activated by key disease associated proteases such as Cathepsin B, L, S and Plasmin. ProSense 680 is optically silent in its unactivated state and becomes highly fluorescent following protease-mediated activation. ProSense 680 can be used as a marker for disease progression and therapeutic response in animal models of arthritis. This agent can also be used as a marker for disease progression in animal tumor models.