In order to investigate minute quantities of impurities in such areas as pharmaceuticals and pesticide residues in food products, both the ability to separate and detect trace compounds more reliably and increased analysis efficiency are required.

Utilizing features of the Prominence UFLC, which offered high speed as well as high analysis accuracy and reliability, thereby increasing analysis cost-efficiency, we have developed the Prominence UFLCXR, which achieves greater data quality by means of higher separation performance.

While maintaining the high analysis accuracy and reliability cultivated with the Prominence series by using a high-speed separation column and optimizing the system, we have increased separation performance to a level greater than that of conventional LC.

The Ultimate in High Separation Performance

The ability to reliably perform the high-separation, high-sensitivity detection of trace compounds is required. Improving separation performance by simply increasing the column length also increases the analysis time, which reduces analysis efficiency.

With the Prominence UFLC, high-speed analysis while maintaining a high degree of analysis accuracy and reliability is possible and with the Prominence UFLCXR, greater separation performance is attained. In order to achieve the ultimate in high separation performance, column efficiency has been improved by optimizing the balance between the particle diameter of the XR-ODS and XRII-ODS high-speed separation column and the column length, and the system has been optimized to attain the highest possible level of column performance.

High-Sensitivity Detection of Trace Components

The combination of the Prominence UFLCXR and a Shim-pack XR-ODS II column (length: 150 mm) achieves a level of separation performance equivalent to that of at least a 250-mm column containing packing material with a particle diameter of 5 µm. The wide dynamic range of the SPD-20A detector enables the high-separation, high-sensitivity detection of fine peaks, such as those obtained for minute quantities of impurities in pharmaceuticals, and thereby enables highly reliable analysis in which the slightest presence of impurities is not missed. Also, the low-carryover SIL-20AXR autosampler supports high-accuracy analysis.