Status:
ReviewerMember since: 2018
Organization: Advanced Enzyme technologies
A must-have for biophysical characterization of proteins.
Application Area: Analyze protein samples
"This is a very useful instrument if you are into protein characterization. It gives you valuable information on stability, and behaviour of the protein under several different conditions. One can process many samples in a short time, hence this is good for screening purposes. The data obtained would otherwise take a long time with other methods. Therefore one can make quick decisions. The instrument is easy to use and the data is easy to analyze."
Status:
ReviewerMember since: 2020
Organization: Syngene International
Great.
Application Area:Protein sample analysis
"High quality and reproducible data, high throughput and best customer service."
Status:
ReviewerMember since: 2017
Organization: DuPont IB/ Genencor
This is a great instrument!
Application Area:Formulations
"Gives us reproducible data, consistently. No sample prep is needed which saves time."
Status:
ReviewerMember since: 2016
Organization: Sanofi R&D
Great instrument! Robust, easy to use, cost- and time-effective in operations!
Application Area:Small molecules and Biologics projects in drug discovery research
"Prometheus is very reliable and easy to use instrument that is delivering very high quality results, for both small molecules and biologics results. Its use is extremely time- and cost-effective. This instrument is one of the most used in our multi-disciplinary teams where we apply great number of biophysical instruments and dealing with >60 companies/vendors"
Status:
ReviewerMember since: 2016
Organization: Inst. for Stem Cell biology & Regenerative Medicine
Wonderful instrument and easy usage
Application Area:Tm of membrane proteins
"The Prometheus NT48 is a very convenient way for us to test the efficacy of various chemicals that affect membrane protein stability. The small sample volume and relatively high throughput of the system makes additive selection for membrane proteins very easy."
Status:
ReviewerMember since: 2016
Organization: 2bind GmbH
Fast and precise information on formulation of therapeutic antibodies.
Application Area:Preformulation of therapeutic antibodies
"Our company 2bind uses the nanoDSF to optimize the formulation of therapeutic antibodies. The Prometheus allows us to screen 48 buffer conditions with a bit more than an hour. The antibody can be used as it is - without any modification - and in a very broad concentration range. Due to the capillary format the method consumes only low sample material. NanoDSF allows us to study thermal stability (Tm) and aggregation onset temperature within one experiment. The high data point density enables to see even smallest transition points. Output data are highly comparable to DSC, but obtained faster, with less material and less costs. The Prometheus device is very robust and occupies only small lab space. We can definitely recommend this technology as nanoDSF has become a standard application in our lab."
Status:
ReviewerMember since: 2016
Organization: Targenomix GmbH
It perfectly complements our workflow of protein biochemistry analytics.
Application Area:Analyze enzyme stability and ligand binding
"The Prometheus solved a crucial step in our protein biochemistry workflow: we are able to quickly, efficiently and cost efficiently analyze the melting behavior of enzymes."
The Prometheus NT.48 measures thermal unfolding and turbidity in parallel using near-UV detection systems. With nanoDSF and backreflection technologies, researchers can make better decisions about the stability of their protein formulations while using small volumes of sample. It is a great addition to any lab interested in small-scale thermal shift assays, profiling mutant protein behavior, or formulating storage and assay buffers.
Key Features:
Manufacturer NanoTemper Technologies | Available Worldwide
4.9 / 5.0 | 7 reviews