Progenesis QI by Nonlinear Dynamics

"We are still learning the different functionalities of the system. So far we are agreably surprised by the capacity of the system."

"The software can't process data that is acquired in both positive/negative mode. Annotation tools are limited to a few options, which does not include in-silico fragmentation. Training videos/tutorials are still missing."

"Progenesis is great, a good tool for the laboratory for doing untargeted metabolomics applications. The ability to do feature extraction, chromatographic alignment and differential expression is an invaluable tool!"

"We have tried more than half a dozen applications for untargeted mass spec analysis, and QI is by far the fastest, most powerful, and most stable. Unfortunately it is very expensive."

"Very consistent results, user friendly software. Successfully used in all my projects."

"Progenesis QI is a very good software for people wanting to find differentially expressed small molecules using LC-MS. The workflow is very easy to understand for non-MS specialist and it's very easy to obtain meaningful data in particular since the implementation of MS/MS database like METLIN."

"Great and easy to use. Saves much time and effort."

"The software gives me a good start and overview to the sample set and helps when thinking about further research steps, I had trouble exporting some information to Excel which I found annoying, but I received help very quickly which resolved the issue."

"I think it’s a great product for someone wanting to obtain quick results after injecting hundreds of samples a week. Progenesis QI for small molecules is very friendly and easy to use once you get familiar with the software. The challenge is to create your one database focused in your area of research. Reviewing your compounds and the statistics is also very helpful when you want to present your results in an easy way."

"Easy to use; produces reliable data; great statistics, nice outputs from all levels of analysis for presentation; needs a bit time to fully understand the power of complex filter settings"

"This software is very easy to use and useful in non-target analysis, like peak picking and identification."

"Progenesis QI, a powerful software for metabolomics study, is very convenient and easy control. Although expensive, it’s worth the money, we have done a project with 1000 samples. The identification of metabolites, which is the bottlenecks of metabolomics and lipidomics study, have improved a lot in QI. I'm really looking forward to the constantly development of Progenesis QI. "

"The conversion of several raw spectral files into a data matrix is usually difficult and a time consuming task. Progenesis QI changed all that at our institution. The ability of the program to handle more than one “recording” channel and its use of in silico fragmentation are key features that we cannot go without."

"A massive improvement over MarkerLynx for metabolomic analyses. Still has a few bugs, but should be perfect by version 3. "

"Progenesis QI is straight-forward to use and can be integrated into a laboratory workflow with relative ease."

"Provided a good first screen for quantitative differences and was fairly straightforward to use. Very good support - always happy to help, advise and listen to concerns."

"We have found Progenesis QI to be incredibly useful for our proteomics and metabolomics work. It speeds time to compound identification and provides very useful comparison tools for our datasets."

"Jonathan McSayles has been a pleasure to work with. He has gone to extra mile to stay patient as we go through our purchasing and installation processes. Progenesis QI is far and away the best product for analyzing mass spectrometry based metabolomic data. "

"Excellent product. The next steps would be to include machine learning approaches in the analyses performed."

"I use this software for data analysis from LC-MS/MS Waters raw files. The statistical part of software is very useful; and from the raw data files we can get the statistical results."

"Progenesis QI is an easy-to-use and practicable tool in untargeted metabolite analysis. Even the students can use it without supervision. Our group use ProGenesis QI in versatile projects from functional genomics to perturbation analysis."