The Portrait™ 630 spotter is the latest innovation from Labcyte Inc. The Portrait 630 is a fully automated, non-contact, nozzle-free acoustic droplet ejection system optimized to deposit MALDI matrix and other reagents onto tissue sections and other samples for precision MALDI imaging mass spectrometry. Multi-step protocols, precise drop-on-drop positioning and flexible droplet timing automate sequential experiments such as tryptic digests followed by matrix deposition. Automated reagent deposition using the Portrait 630 spotter improves crystal formation, yielding higher quality, more sensitive, and more reproducible mass spectra.