PKL Chromatography Systems for Process Development by Pall Life Sciences Products - Biopharmaceutical Division
The suite of PKL bench-top chromatography systems is designed for rapid method and process development across a broad spectrum of biotherapeutics such as proteins, peptides, plasmids and viruses. The result is a blend of unique advantages and user features which are unmatched in the industry. The high dynamic flow range of the systems enables suitability for all formats of chromatography: conventional column, expanded bed, and membrane chromatography. Other key features include powerful, easy-to... Read more
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PKL Chromatography Systems for Process Development
The suite of PKL bench-top chromatography systems is designed for rapid method and process development across a broad spectrum of biotherapeutics such as proteins, peptides, plasmids and viruses. The result is a blend of unique advantages and user features which are unmatched in the industry.
The high dynamic flow range of the systems enables suitability for all formats of chromatography: conventional column, expanded bed, and membrane chromatography. Other key features include powerful, easy-to-use Windows-based software, an active air trap, a multimode detector and a 100:1 pump-turndown ratio.
Developed from proven systems, with many years experience and a large customer base, PKL systems are also part of the Pall family of PK chromatography systems. The PK software wizard enables easy transfer of optimized methods from the PKL systems to process-scale PK chromatography systems. This allows optimum flexibility for changing process demands.
Features
• Automates buffer delivery, column switching, fraction collection based on UV / pH or conductivity
Complete automation of chromatography process allowing 24-hour operation
• Large dynamic flow range: 1 – 100 mL /min or 10 – 1000 mL /min
Greater flexibility allows use of expanded bed, membrane chromatography and TFF capsules
• Graphical, intuitive software for easy operation and training
• Precision Hardware
100:1 turndown ratio for accurate gradients (5 – 95% capability)
Low system hold up volume minimizing sample dilution
Integrated pH, UV and temperature sensors reduced lag time between detectors compacting the flow path
• Automated GMP reports
Complete batch report logging of all critical data required for regulatory support
• Safety Features
Active air trap protects column from any amount of air
Leak and pressure alarms
Built in safety interlocks
Software method checks
• Chromatogram overlay and data analysis
Comparison of batch run data or key process variables during scouting
• Software security prevents unauthorized operation and tampering of data ensuring compliance with 21 CFR part 11 requirements
• Scale up-scale down studies
Process troubleshooting or small scale validation studies
The high dynamic flow range of the systems enables suitability for all formats of chromatography: conventional column, expanded bed, and membrane chromatography. Other key features include powerful, easy-to-use Windows-based software, an active air trap, a multimode detector and a 100:1 pump-turndown ratio.
Developed from proven systems, with many years experience and a large customer base, PKL systems are also part of the Pall family of PK chromatography systems. The PK software wizard enables easy transfer of optimized methods from the PKL systems to process-scale PK chromatography systems. This allows optimum flexibility for changing process demands.
Features
• Automates buffer delivery, column switching, fraction collection based on UV / pH or conductivity
Complete automation of chromatography process allowing 24-hour operation
• Large dynamic flow range: 1 – 100 mL /min or 10 – 1000 mL /min
Greater flexibility allows use of expanded bed, membrane chromatography and TFF capsules
• Graphical, intuitive software for easy operation and training
• Precision Hardware
100:1 turndown ratio for accurate gradients (5 – 95% capability)
Low system hold up volume minimizing sample dilution
Integrated pH, UV and temperature sensors reduced lag time between detectors compacting the flow path
• Automated GMP reports
Complete batch report logging of all critical data required for regulatory support
• Safety Features
Active air trap protects column from any amount of air
Leak and pressure alarms
Built in safety interlocks
Software method checks
• Chromatogram overlay and data analysis
Comparison of batch run data or key process variables during scouting
• Software security prevents unauthorized operation and tampering of data ensuring compliance with 21 CFR part 11 requirements
• Scale up-scale down studies
Process troubleshooting or small scale validation studies
Product Overview
PKL Chromatography Systems for Process Development
Manufacturer Pall Life Sciences Products - Biopharmaceutical Division
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