PCSK9 mice were created utilizing a full-length human PSK9 cDNA with a C-terminal V5 tag expressed under the transcriptional control of a composite human albumin promoter containing a 235 bp SV40 enhancer and a 213 bp albumin promoter element.
A chimeric intron was inserted between the promoter and PCSK 9 cDNA to enhance expression. The expression cassette was flanked by a 1.2 kb insulator sequence from the chicken beta-globulin gene at both the 5’ and 3’ ends of the transgene. The expression c... Read more
The supplier does not provide quotations for this product through SelectScience. Browse these related products instead
Related Products
PCSK9 Mouse
The supplier does not provide quotations for this particular product through SelectScience. You can search for similar products in our product directory.
PCSK9 mice were created utilizing a full-length human PSK9 cDNA with a C-terminal V5 tag expressed under the transcriptional control of a composite human albumin promoter containing a 235 bp SV40 enhancer and a 213 bp albumin promoter element.
A chimeric intron was inserted between the promoter and PCSK 9 cDNA to enhance expression. The expression cassette was flanked by a 1.2 kb insulator sequence from the chicken beta-globulin gene at both the 5’ and 3’ ends of the transgene. The expression construct was injected into the pronucleus of fertilized eggs from C57BL6J/N mice and the resulting founders and their transgenic offspring were identified from tail tissue by a PCR product amplified from the insulator sequence. Transferred to Charles River under exclusive license from Pfizer Inc., in 2011.
Model Properties:
- Coat Color Black
- Ideal For: Cholesterol regulation
- Strain Code: 531 HE, 532 HO, 533 WT, This model is cryopreserved.
Product Overview
